2 edition of Safety problems related to chloramphenicol and thiamphenicol therapy found in the catalog.
Safety problems related to chloramphenicol and thiamphenicol therapy
Includes bibliographical references and index.
|Statement||editors, Y. Najean, G. Tognoni, Adel A. Yunis.|
|Series||Monographs of the Mario Negri Institute for Pharmacological Research, Milan|
|Contributions||Najean, Yves., Tognoni, Gianni., Yunis, Adel A.|
|LC Classifications||RM666.C516 S23|
|The Physical Object|
|Pagination||x, 118 p. :|
|Number of Pages||118|
|LC Control Number||80005838|
Because chloramphenicol can cause aplastic anemia in humans, its use in humans has greatly diminished, and it is only used for the treatment of MDR bacterial infections where few or no other antimicrobial drugs are useful. Thiamphenicol and florfenicol are related compounds, the availability of which varies from country to country. 1. Clin Ter. Aug 15;86(3) [Chloramphenicol and thiamphenicol]. [Article in Italian] Mariani L. PMID: [PubMed - indexed for MEDLINE].
Chloramphenicol and its derivatives, thiamphenicol and florfenicol, reversibly bind to the 50S ribosome subunit, resulting in protein synthesis inhibition. They are bacteriostatic. Competitive antagonism may occur when co-administered with macrolide antibiotics, since they share the same site of action. Duck PD, Dillon JR, Eidus L. Effects of thiamphenicol and chloramphenicol in inhibiting Neisseria gonorrhoeae isolates. Antimicrob Agents Chemother. Nov; 14 (5)– [PMC free article] Finland M. Changing ecology of bacterial infections as related to antibacterial therapy. J Infect Dis. Nov; (5)–
Chloramphenicol is a relatively stable compound and is unaffected by boiling, provided that a pH of 9 is not exceeded. The nitrophenol group of chloramphenicol is replaced by a methyl sulfonyl group for thiamphenicol and florfenicol; florfenicol also contains a fluorine molecule. These structural changes improve efficacy, reduce toxicity, and. Two related antibiotics, thiamphenicol and its derivative, florfenicol, were developed by substituting a methyl sulfonyl group for the nitrophenol group that characterizes chloramphenicol. Thiamphenicol and florfenicol are both safer compounds; the former is less effective than chloramphenicol and the latter is more effective than.
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Author(s): Najean,Yves; Tognoni,Gianni; Yunis,Adel A Title(s): Safety problems related to chloramphenicol and thiamphenicol therapy/ editors, Y. Najean, G. Tognoni.
Chloramphenicol is a stable, lipid‐soluble, neutral compound. It is a derivative of dichloracetic acid and contains a nitrobenzene moiety.
This p‐nitro group is associated with idiosyncratic (non‐dose‐dependent) aplastic anemia in henicol has a similar antibacterial spectrum to chloramphenicol but differs from the parent compound in that the p‐nitro group attached to the Cited by: Chloramphenicol may interfere with a number of drugs, chiefly because of its hepatic metabolism.
This interference has not been described with thiamphenicol. The principal problem of tolerance relates to chloramphenicol and the possibility of induction of hematologic accidents that are often irreversible and fatal.
Types of haemopoeitic inhibition by chloramphenicol and thiamphenicol. In: Safety Problems Related to Chloramphenicol and Thiamphenicol Therapy, Najean Y, Tognoni G, Yunis AA (eds). Raven Press, New York, pp 43 — Cited by: Safety Problems Related to Chloramphenicol and Thiamphenicol. New York: Raven Press; pp.
43– Festing MFW, Diamanti P, Turton J. Strain differences in haematological response to chloramphenicol succinate in mice: implications for toxicological research. Chloramphenicol and Tiamphenicol inhibit bacterial protein synthesis and have bacteriostatic activity.
Chloramphenicol is relatively toxic, and can cause severe agranulocytosis. It crosses the placenta well and can reach therapeutic concentrations in the fetus. In premature and term births it may lead to the grey baby syndrome.
Metabolism Metabolic pathways of Thiamphenicol in human was studied by y et.a1.(8), and Nakagawa (10). and are based on the known metabolic pathways for chloramphenicol. Thiamphenicol was transformed into the glucuronic acid conjugation of Thiamphenicol, and/or hydrolysis of the dichloroacetamido group took place with or without.
Yunis, A.A., Chloramphenicol toxicity and the role of thep-NO 2 in aplastic anemia. In: J. Najeanet al. (eds.),Safety Problems Related to Chloramphenicol and Thiamphenicol Therapy, (Raven Press, New York), 17– Google Scholar.
This may cause more chance of getting an infection, bleeding problems, or slow healing. Aplastic anemia that happened with chloramphenicol has led to a certain kind of cancer (leukemia).
Blood problems have happened after both short-term use and long-term use. Have your blood work checked while taking chloramphenicol. Najean Y () International symposium on safety problems related to Chloramphenicol and Thiamphenicol therapy: Comparative epidemiological data on Chloramphenicol and Thiamphenicol from the french multiclinic monitoring of aplastic anemia.
Milan, May 8 th Chloramphenicol (CAP), florfenicol (FF), and thiamphenicol (TAP) were extracted from yellowtail muscles with ethyl acetate, and the extract was evaporated. The residues was dissolved with sodium chloride solution and partitioned with n-hexane to remove lipids, and then the drugs were extracted with ethyl acetate.
After evaporation of ethyl acetate extract, the residue was dissolved with n. It is dose-dependent, occurring regularly at chloramphenicol dosages exceeding 4 g/day (in adults) or at plasma drug concentrations >= 25 mcg/mL, and usually responds to withdrawal of the drug. Therapy with chloramphenicol should be administered cautiously, if at all, in patients with preexisting blood dyscrasias and/or bone marrow depression.
Safety problems related to chloramphenicol and thiamphenicol therapy by Gianni Tognoni, Adel A. Yunis, Yves Najean Pages, Published by Raven Press ISBN. Chloramphenicol (CAM) is the D-threo isomer of a small molecule, consisting of a p-nitrobenzene ring connected to a dichloroacetyl tail through a 2-amino-1,3-propanediol moiety.
CAM displays a broad-spectrum bacteriostatic activity by specifically inhibiting the bacterial protein synthesis. In certain but important cases, it also exhibits bactericidal activity, namely against the three most.
The effect of chloramphenicol and a chloramphenicol analog, thiamphenicol, on the growth of bone marrow colony-forming cells in agar was investigated. At concentrations within therapeutic range, both drugs cause a marked reduction in the number of colonies and in the size of aggregates, indicating suppressed cellular proliferation.
Della Bella D,Biological properties of chloramphenicol as related to structural features: from classical knowledge to future developments, in Najean Y, Togoni G, Yunis AA, ed, Safety Problems Related to Chloramphenicol and Thiamphenicol Therapy, Raven Press, New York, p 31 – Assay of the Related Compounds Thiamphenicol, Florphenicol, and Chloramphenicol by CE Article (PDF Available) in Chromatographia 68(7) October.
Thiamphenicol (also known as thiophenicol and dextrosulphenidol) is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is to 5 times as potent.
Like chloramphenicol, it is insoluble in water, but highly soluble in lipids. In man, chloramphenicol (CAP), induces two major haemotoxic effects. First, a reversible, dose-related reticulocytopenia and anaemia developing during treatment.
Second, a non-dose-related aplastic anaemia (AA), developing weeks after treatment, is often irreversible and fatal. The pharmacokinetics of florfenicol (FF), thiamphenicol (TP) and chloramphenicol (CP) after single intravenous (i.v.) or oral (p.o.) administration was studied in an independent cross‐over study in.Thiamphenicol is an antibiotic that has been used to treat chancroid in men and uncomplicated gonorrhea.
It is used in studies of bacterial protein synthesis at the level of peptidyl transferase activity associated with the 23S rRNA of the 50S ribosomal subunit.Chloramphenicol is a bacteriostatic antimicrobial that became available in It is considered a prototypical broad-spectrum antibiotic, alongside the tetracyclines, and as it is both cheap and easy to manufacture it is frequently found as a drug of choice in the third world .
Chloramphenicol is effective against a wide variety of Gram-positive and Gram-negative bacteria.